An anonymous woman tries to disentangle a shopping cart from an interlocked row of them, outside a suburban store. She is frustrated and angry. She becomes even more exasperated when another shopper enters the frame, calmly unhooks a cart and glides smoothly on her way. Watching this TV advertisement unfold, it might look like the woman is experiencing little more than a normal bout of tension or stress. But the folks at the drug company Lilly know better. This woman may need a powerful antidepressant because she is suffering from a severe form of mental illness known as PMDD. “Think it’s PMS? It could be PMDD,” intones the voiceover.
Columbia University Professor Jean Endicott tells us premenstrual dysphoric disorder (PMDD) is a psychiatric condition suffered by up to 7 percent of women. Paula Caplan of Brown University claims that the condition has essentially been invented and that there is no strong scientific evidence to distinguish it from normal premenstrual difficulties. Even worse, argues Caplan, using a medical label to explain away the severe distress some women experience in the lead-up to their period runs the risk of masking the underlying causes of their suffering.
In the United States, the Food and Drug Administration has accepted that the condition PMDD exists and has approved Lilly’s Prozac and several similar antidepressants for its treatment, yet in other parts of the world it is not even a recognized disease. It is not listed as a separate disorder in the World Health Organization’s International Classification of Diseases. And even in the United States, despite the hard work of Endicott, Lilly and other pharmaceutical companies, PMDD still has only a partial listing in the psychiatrists’ manual of diseases, the DSM, and is therefore not seen as a fully official category of illness.
Yet this scientific controversy is invisible in the avalanche of television and magazine advertisements about PMDD in the United States–much of it targeting young women. The $500 billion pharmaceutical industry has identified another new mega-market–women of childbearing age–and the world of marketing demands simple, clear messages. The emotional ups and downs preceding your period are no longer a part of normal life–they are now a telltale sign you could have a psychiatric condition. As Caplan puts it, by watching these ads “women are learning to consider themselves mentally ill.”
A friendly and hardworking academic, Endicott operates from a small office buried in the basement of a psychiatric hospital in New York City. In stark contrast to Caplan, she insists PMDD is a genuine disorder that can be “very disabling” and is often not properly diagnosed or treated. She welcomes drug company efforts to have the condition taken more seriously. It was Endicott who led the key scientific meeting–funded by Lilly and attended by company representatives–that paved the way for two of the most important developments in the life of this young disorder: FDA acceptance of the condition and approval of Lilly’s antidepressant as the first drug to treat it. As to the appropriateness of drug companies advertising disorders like this on television, Endicott is a strong believer. “I think it educates people,” she says.